From: Chandra Boon <boon@uhnres.utoronto.ca>
  To  : rasmb@alpha.bbri.org
  Date: Thu, 26 Apr 2001 14:50:24 -0400 (EDT)

Weighted vs nonweighted fits

Hello.  I am using the Beckman software (Origin) to analyse some
sedimentation equilibrium data.  I obtained fairly different results (for
Ka and the variance) when using the weighted vs the nonweighted fit for
the same model.  What is the difference between the two fits and which
one is more reliable?  Thanks.

Chandra Boon
Dept. of Medical Biophysics
University of Toronto