From: Peter Schuck <pschuck@helix.nih.gov>
  To  : rasmb@alpha.bbri.org
  Date: Mon, 07 Feb 2000 14:01:05 -0800

new version of sedfit

Dear RASMBers

A new version (3.2) of sedfit is now available for download from the RAMSB
ftp-site (ftp://rasmb.bbri.org/rasmb/spin/ms_dos/sedfit-schuck/), of from
Borries Demeler's ultracentrifugation website
http://www.cauma.uthscsa.edu/software. 

The software runs on Windows 95, 98 or NT and allows direct and fast
analysis of sedimentation velocity data.  While the main feature of the
software are Lamm equation models, the new version has been extended to
incorporate several other analysis types, for example g*(s). 

new features:
* g*(s) analysis by direct least-squares boundary modeling
* continuous size-distributions c(M) and c(s) distributions by Lamm
equation modeling
* analysis of flotation coefficients
* a simple van Holde-Weischet analysis

* Monte-Carlo statistics for distribution analysis
* Runs test Z (as described in Straume & Johnson, Methods Enzymol 1992)
* calculation of confidence intervals for s,M (with F-statistics) is more
automated

* calculator for frictional ratios, axial ratios
* calculator for variance ratios (F-statistics)
* concentrations now remain always positive by using NNLS from Lawson & Hanson
* includes Lamm equations for other geometries (e.g. external loading cells)

* subtract blank scan utility
* remove integral fringe jump in interference scans utility
* scaled residuals bitmap for diagnosing systematic deviations

and several bugs were fixed

The software is free, requires a Pentium > 200MHz, with > 64 MB RAM, and it
has a extensive integrated help system that describes in detail all
features and how to use them.  

Please let me know if you have any problems in using it, or if you have any
suggestions for possible changes or extensions.

Best regards,
Peter

***********************************************************
Peter Schuck, PhD
Molecular Interactions Resource
Bioengineering and Physical Science Program, ORS
National Institutes of Health
Bldg. 13 Rm. 3N17
13 South Drive 
Bethesda, MD 20892 - 5766
Tel: (301) 435-1950
Fax: (301) 496-6608
email: Peter_Schuck@nih.gov
***********************************************************