From: Borries Demeler <demeler@bioc09.uthscsa.edu>
  To  : ultrascan@bioc09.uthscsa.edu
  Date: Sat, 22 May 1999 15:47:09 -0500

Announcing UltraScan 4.0 data analysis software

Dear Analytical Ultracentrifugation User:

Version 4.0 of UltraScan II for Unix has been released and is available
for download (free) from:

	http://www.ultrascan.uthscsa.edu

This version includes many new important features and bugfixes. If
you have an earlier version of UltraScan you are urged to upgrade.
Precompiled binaries for several Unix flavors, including Intel Linux,
DEC Alpha OSF and SGI Mips/Irix are provided. Screenshots of the program
can be found at:

	http://www.ultrascan.uthscsa.edu/screenshots.html

UltraScan II is a comprehensive and user-friendly GUI data analysis
environment for sedimentation experiments. 

Some of the features include:

GENERAL:

* Complete online context specific help & documentation
* Consistent and intuitive user interface for all functions
* Integrated data editing routine, edited data is saved in efficient
  binary format and can be analyzed by all applicable analysis methods
* Absorbance optics support
* Interference optics support with baseline correction capability
* On-line movies of interference data
* Centerpiece support for 2/6 channel, synthetic, epon and aluminum
* Automatic correction for AN50/60 rotor stretching
* unlimited number of datascans/analysis (well, limited by your
  computer's memory)
* all output is provided as GUI, postscript and ASCII files
* integrated with Swiss Protein Database
* Run diagnostics (automatically determines number of cells, scans, 
  wavelengths, speeds, temperature variations, rotor acceleration corrections, 
  run duration, etc. for an entire run)
* Support contracts available (for installation, training, maintenance, 
  and data analysis)

ANALYSES:

* van Holde - Weischet analysis, extrapolation plots and G(s) distributions
* Finite Element whole boundary fitting analysis, include molecular 
  modeling routine
* Second Moment analysis
* Time Difference Analysis (dC/dt)
* Radial Different Analysis (dr/dt)
* Equilibrium Analysis support
* Runtime user-selectable smoothing (sliding gaussian kernel)
* Runtime data cropping (excluding/including of selected scans and scan ranges)
* Runtime boundary/concentration cropping/shifting

SIMULATIONS:

* Finite Element simulations for velocity and approach-to-equilibrium
  experiments, supporting unlimited number of components for ideal and
  non-ideal non-interacting systems, monomer-dimer equilibria, and a
  2-state isomerization system. Also supported are random gaussian noise
  as well as time invariant gaussian noise, concentration dependency of s 
  and D. Run Parameters can be set from a simulated instrument control
  panel. Simulated data can be analyzed with van Holde - Weischet,
  Second Moment, DCDT and DCDR. Great for teaching a graduate level
  course in sedimentation! Provides movies of sedimentation process.
* Self-association equilibration simulation for monomer-dimer and 
  monomer-dimer-tetramer systems
* Utility for modeling s, D and f from MW and axial ratio for 4 basic shapes 
* Utiltiy for predicting molecular dimensions from MW and s, MW and D, 
  or s and D for 4 basic shapes 

UTILITIES:

* Equilibrium experiment speed calculation 
* Builtin buffer tables (J. Philo's Sednterp)
* Builtin V-bar correction 
* Builtin temperature correction
* Raw datafile archiving
* Scan file re-ordering utility
* Linux only: graphical system state monitors
* Utility to combine van Holde - Weischet analysis G(s) distributions
* Data archiving

OTHER LINKS:

* Changelog for UltraScan II upgrade from version 3.0 to 4.0:
  http://www.ultrascan.uthscsa.edu/changelog.html

* Support options for UltraScan:
  http://www.ultrascan.uthscsa.edu/support.html

* Order Software on CD-ROM:
  UltraScan: http://www.ultrascan.uthscsa.edu/order_us.html
  Linux: http://www.ultrascan.uthscsa.edu/order_linux.html

* UltraScan Mailing List:
  http://www.ultrascan.uthscsa.edu/mlist.html
  
* UltraScan on-line Manual:
  http://www.ultrascan.uthscsa.edu/manual

* UltraScan Frequently Asked Questions (FAQ)
  http://www.ultrascan.uthscsa.edu/faq.html

* UltraScan License:
  http://www.ultrascan.uthscsa.edu/license.html

* Center for Analytical Ultracentrifugation of Macromolecular Assemblies:
  http://www.cauma.uthscsa.edu/

If you find any bugs in the software or documentation please report them to 
the UltraScan mailing list at:

	http://www.ultrascan.uthscsa.edu/mlist.html

Thanks, and happy analysis!

-Borries Demeler	

-------------------------------------------------------------------------------
This work has been funded by the National Science Foundation, the
Howard Hughes Medical Institute and the Dept. of Biochemistry at
the University of Texas Health Science Center at San Antonio, Texas, USA
-------------------------------------------------------------------------------
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*******************************************************************************
* Borries Demeler                                                             *
* The University of Texas Health Science Center at San Antonio                *
* Dept. of Biochemistry, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7760 *
* Voice: 210-567-6592, Fax: 210-567-4575, Email: demeler@biochem.uthscsa.edu  *
*******************************************************************************