From: Lumelle A. Schmiedekamp <lxs28@cac.psu.edu>
  To  : rasmb@bbri.harvard.edu
  Date: Mon, 26 Apr 1999 14:44:07 -0400 (EDT)

Diffusion Coefficient with Dynamic info for a protein?

A colleague in the department asked me if it is possible to determine not
only shape information from sedimentation velocity, but also to determine
the degree of dynamic movement of outer domains of a protein.  My thought
was that a largely dynamic domain should increase the frictional
coefficient and therefore decrease the diffusion coefficient.  However,
without a rigid control protein of the same shape, I do not know how to
measure this type of dynamic effect.  Any suggestions or ideas would be
much appreciated.

Thanks.
Lumelle

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