From: Lee, James C. <jclee@utmb.edu>
  To  : 'RASMB' <rasmb@alpha.bbri.org>
  Date: Tue, 30 Nov 1999 15:26:36 -0600

Postdoc Announcement

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> I am writing to solicit your help in identifying candidates for two to
> three
> postdoctoral positions in my laboratory.  I would appreciate it if you
> could
> post the enclosed announcement.
> 
> Multiple openings are available to elucidate the mechanism in modulating
> specific DNA sequence recognition by E.coli AMP receptor protein (CRP).
> Recent studies from this laboratory indicate that in the lac operon, the
> two
> half sites in the DNA contribute twice as much energetically as the
> flanking
> sequence towards DNA-CRP recognition, however, in the gal operon, the
> flanking sequence contributes more (Biochemistry 37, 5194, 1998).  The
> observation of differential energetic contributions by the flanking
> sequences and the half-sites in DNA recognition is linked to the extent of
> CRP-induced bending in gal and lac (Biochemistry 37, 5201, 1998).  In
> addition, we have identified some residues in CRP, in conjunction with
> cyclic nucleotides, as key players to modulate CRP in its recognition for
> specific DNA sequence.  Thus, the dynamics of both DNA and CRP must play
> important roles in defining recognition.  The approaches employed include
> molecular biology, biophysical solution chemistry, and through
> collaboration
> with my colleagues, X-ray crystallography (Robert Fox), NMR spectroscopy
> (David Gorenstein) and computational chemistry (Vince Hilser).
> 
> Candidates with a Ph.D. in biochemistry/biophysical chemistry/molecular
> biology and are interested in extending their experience in different
> areas
> are particularly encouraged to apply.  Please send CV, names and addresses
> of three references to me.
> 
> Dr. James C. Lee
> University of Texas Medical Branch
> Department of Human Biological Chemistry and Genetics
> 5.138 Medical Research Building
> Galveston, TX 77555-1055
> Tel: (409) 772-2281, Fax: (409) 772-4298
> e-mail: jlee@hbcg.utmb.edu <jlee@hbcg.utmb.edu>">mailto:jlee@hbcg.utmb.edu> 
> http://WWW.hbcg.utmb.edu/faculty/lee/lee.html
> <http://WWW.hbcg.utmb.edu/faculty/lee/lee.html> 
> 
> 
> Sincerely,
> James C. Lee
> R.A. Welch Chair in Chemistry and Professor
> 
> 
>  <<Postdoctoral Announcement.doc>>  

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