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  From: yujia xu <>
  To  :
  Date: Tue, 24 Mar 1998 11:34:16 -0500

analysis of heteromeric system

For the analysis of heteromeric system using equilibrium sedimentation,
commercial mathematicl modeling software packages could be usefull, but
acctually NONLIN can do all the work with little or no modification. The
parameter 'n' in NONLIN, which stands for 'the degree of association' does not
have to be an interger. For self-associating systems n is set to 2 for
dimerization, 3 for trimerization etc.. For heteromeric association, the n can
be set to the  ratio of the molecular weight of the two types of monomer
involved in the interaction, and the analysis can be carried out as one would
for a self-association system.


Yujia Xu
Department of Biochemistry and Biophysics
University of Pennsylvania, School of Medicine
Philadelphia, PA 19104
(215) 898-6580

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