From: Peter Schuck <pschuck@helix.nih.gov>
  To  : Robert Fairman <rfairman@haverford.edu>
  Date: Sun, 22 Mar 1998 20:16:44 -0500

Re: se analysis of heteromeric systems

What we use for all our sedimentation equilibrium analyses (including any
homogenous, heterogenous, or mixed interactions, multi-wavelength analyses,
single scan or global analyses) is simply a powerful commercial
mathematical modeling software package (For example, several different such
packages are discussed and compared in Nash JC, Quon TK (1996) Am Statist,
50:368-377).

The big advantage is (and initially that may be a disadvantage, too) that
you can define the model functions yourself, e.g. in a short script file,
which allows you to tailor the data analysis precisely to your system and
what you know about it.  This can be very fast and general. Would be happy
to share some of the scripts that I wrote. 

Peter Schuck


At 06:44 PM 3/20/98 -0500, you wrote:
>Does anyone have software for general analysis of heteromeric systems?  I
>particularly like the NONLIN program and was also wondering if any plans to
>include heteromeric models are in the works?
>
>____________________________
>  Robert Fairman
>  Department of Biology
>  Haverford College
>  370 Lancaster Ave
>  Haverford, PA  19041
>  email: rfairman@haverford.edu
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>  fax          - 4963
>____________________________
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>