From: Gary Knott <knott@civilized.com>
  To  : rasmb@bbri.harvard.edu
  Date: Wed, 23 Apr 97 15:55:41 -0400

Re: heterogeneity calculation

(Jeffry C. Nichols wrote:)

>>As most of you already know, the Beckman software is not set up
>>to examine heterogeneic samples.  I would like to determine association
>>rates for a protein/lipo-protein solution, each having different MWs.
>>
>>Are there programs available to handle this?
>>
>>Forgive my ignorance with this type of experiment, as most
>>everything up to this point has been limited to single species.
..................................................

Yes, the MLAB software can be used to fit a sedimentation
curve to estimate an equilibrium constant for a general
binding of two different species.  Please see www.civilized.com;
if you register there, I can send you a paper detailing
the required modeling.---
=================================================================
| Spoken: Gary D. Knott        Email: knott@civilized.com       |
| Phone: (301) 652-4714        NeXT mail and MIME mail welcome  |
| Fax:   (301) 656-1069                                         |
| WWW: http://www.civilized.com/ (Please look at our HomePage!) |
| USPS: Civilized Software Inc., 8120 Woodmont Ave. #250,       |
|       Bethesda, Maryland 20814, USA                           |
=================================================================