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  From: STEVE HARDING <sczsteve@szn1.agric.nottingham.ac.uk>
  To  : RASMB <RASMB@bbri.harvard.edu>
  Date: Mon, 1 Dec 1997 16:41:46 GMT0BST

Micelle determinations

                   Subject:                              Time:  9:43 AM
  OFFICE MEMO         Micelle determinations                Date:  12/1/97

I was wondering if anyone has any experience determining cmc values by
ultracentrifugation.  I know that it's possible but I was hoping for some
advise from anyone that has done this before starting out.  Thanks.

-Judith Boice
Merck Research Labs
Rahway, NJ
908-595-6297

Judith: 
Another recent one to add to the list Richard has given is: S.A. 
Hagan et al (1996) Polylactide-Polyethylene glycol copolymers as drug 
delivery systems - characterisation of water dispersible micelle 
forming systems. Langmuir 12, 2153-2161.  Includes also some 
encapsulation studies.  There is of course a lower concentration 
limit for the u/c. - probably the Wilhelmy plate method (surface 
tension) is more appropriate

Steve Harding 


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