From: Walter Stafford <STAFFORD@bbri.harvard.edu>
  To  : rasmb@bbri.harvard.edu
  Date: Thu, 24 Oct 1996 9:02:13 -0400 (EDT)

Updated version of SEDEQ from Allen Minton is now available

The updated version of Allen Minton's SEDEQ program can be 
downloaded from 

the web:
ftp://bbri.harvard.edu/rasmb/spin/ms_dos/sedeq-minton/sedeq.doc
ftp://bbri.harvard.edu/rasmb/spin/ms_dos/sedeq-minton/sedeq.exe

or

FTP: anonymous ftp to bbri.harvard.edu
path:
/rasmb/spin/ms_dos/sedeq-minton/sedeq.*

This is a VMS system so the path might look like this to some people, 
depending on the FTP client software:
[ANONYMOUS.RASMB.SPIN.MS_DOS.SEDEQ-MINTON]sedeq.*


The following is an excerpt from the documentation file:

PROGRAMS FOR ANALYSIS OF SEDIMENTATION EQUILIBRIUM IN SOLUTIONS 
OF A SINGLE MACROSOLUTE IN THE CONTEXT OF MODELS FOR EQUILIBRIUM

SELF-ASSOCIATION AND/OR NONEQUILIBRIUM MIXTURES OF INDEPENDENTLY 
SEDIMENTING SOLUTES

Allen P. Minton
Laboratory of Biochemical Pharmacology
National Institute of Diabetes, Digestive, and Kidney Diseases 
National Institutes of Health Bethesda, MD 20892 

email: minton@helix.nih.gov

Version 4.1 - October 1995



SUMMARY

   The programs and ancillary files contained in this package can 
be used to analyze sedimentation equilibrium data obtained from 
solutions of a single macrosolute.  At the present time (June, 
1995) we believe that this package is unique in several respects:
   1. It is the only package that allows you to globally fit 
multiple data sets with either equilibrium association or 
nonequilibrium mixture models.
   2. It is the only package that allows you to take into account 
the possible existence of a fraction of "incompetent" solute that 
cannot self-associate, but exists together with and is chemically
indistinguishable from native solute that can self-associate.  
"Damaged" or partially denatured proteins having just these 
properties are commonly encountered in real biochemical 
preparations.
   3. It is the only package that does not require the use of a 
reference concentration as an independently adjustable parameter.