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  From: Jack Correia <jcorreia@umsmed.edu>
  To  : Jim Cole <jim_cole@merck.com>
  Date: Thu, 2 Nov 1995 17:23:04 -0600

Re: Nonideality

Jim,

        You appear to have ruled out the obvious sources.  Is M1 a constant
in your fitter or a variable?  Would errors in M1 or sigma1, ie. possibly
due to vbar errors as well, show up as a poor fit that requires B?   How
about low concentrations of inactive monomers!  Wouldn't that show up as a
decrease of MWapp at higher loads and thus look like B?  Alan Minton has a
program that will allow for inactive species in an associating system.  [I
presume the system is 99% what you think it is with no smaller species.]
Try it and let us know if it helps or works?
|-------------------------------------------------------|
|   Dr. Jack Correia                                    |
|   Department of Biochemistry                          | 
|   Univ. of Miss. Medical Center                       |
|   2500 N. State St.                                   |
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